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Repeated listening to personally meaningful music induces beneficial brain plasticity in patients with mild cognitive impairment or early Alzheimer’s disease, a new study by researchers at the 91�Թ� and Unity Health Toronto suggests.

Changes in the brain’s neural pathways correlated with increased memory performance on neuropsychological tests, supporting the clinical potential of personalized, music-based interventions for people with dementia.

 this week in the Journal of Alzheimer’s Disease.

“We have new brain-based evidence that autobiographically salient music – that is, music that holds special meaning for a person, like the song they danced to at their wedding – stimulates neural connectivity in ways that help maintain higher levels of functioning,” says Michael Thaut, senior author of the study, director of 91�Թ�’s  and a professor in both the Faculty of Music and Temerty Faculty of Medicine.

“Typically, it’s very difficult to show positive brain changes in Alzheimer’s patients. These preliminary yet encouraging results show improvement in the integrity of the brain, opening the door to further research on therapeutic applications of music for people with dementia – musicians and non-musicians alike,” says Thaut, who also holds the tier one Canada Research Chair in Music, Neuroscience and Health.

The researchers reported structural and functional changes in neural pathways of study participants, notably in the prefrontal cortex, the brain’s control centre where deep cognitive processes occur. The researchers showed that exposing the brains of patients with early-stage cognitive decline to autobiographically salient music activated a distinct neural network – a musical network – composed of diverse brain regions that showed differences in activation after a period of daily music listening.

They also observed differences in the brain’s connections and white matter, providing further evidence of neuroplasticity.

“Music-based interventions may be a feasible, cost-effective and readily accessible intervention for those in early-stage cognitive decline,” says Corinne Fischer, lead author, associate professor in the department of psychiatry in the Temerty Faculty of Medicine, and director of geriatric psychiatry at St. Michael’s Hospital, Unity Health Toronto.

“Existing treatments for Alzheimer’s disease have shown limited benefit to date,” she adds. “While larger controlled studies are required to confirm clinical benefits, our findings show that an individualized and home-based approach to music-listening may be beneficial and have lasting effects on the brain.”

For the study, 14 participants – eight non-musicians and six musicians – listened to a curated playlist of autobiographically relevant, long-familiar music for one hour a day over the course of three weeks. Participants underwent structural and task-based functional MRI before and after the listening period to determine changes to brain function and structure. During these scans, they listened to clips of both long-known and new music. Heard one hour before scanning, the new music was similar in style and yet held no personal meaning for the listeners.

When participants listened to the new music, brain activity occurred mainly in the auditory cortex. However, when participants listened to long-known music, there was significant activation in the deep-encoded network of the prefrontal cortex, a clear indication of executive cognitive engagement.

There was also strong engagement in subcortical brain regions, older areas minimally affected by Alzheimer’s disease pathology.

The researchers reported subtle but distinct differences in structural and functional brain changes associated with music listening in musicians relative to non-musicians, though further studies in larger samples are needed to verify these findings. Repeated exposure to music with autobiographical salience improved cognition in all participants, regardless of musicianship.

“Whether you’re a lifelong musician or have never even played an instrument, music is an access key to your memory, your pre-frontal cortex,” Thaut says. “It’s simple: keep listening to the music that you’ve loved all your life. Your all-time favourite songs, those pieces that are especially meaningful to you. Make that your brain gym.”

The 91�Թ�-Unity Health study  with the same participant group that first identified the brain mechanisms that encode and preserve musical memories in people with early-stage cognitive decline.

Next, the researchers plan to replicate the study in a larger sample and institute a strong control condition to investigate the role of musicianship in moderating brain responses, and whether it is the music or the autobiographical content that induces changes in plasticity.